| 16 | Late Show with David Letterman Season 16 Episode 200 – Artie Lange, Todd Barry, Imogen Heap | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 199 – Andy Roddick, Rachael Ray, Mutemath | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 198 – Anne Heche, Jim Parsons, Care Bears on Fire | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 197 – Mary-Louise Parker, Eugene Levy, Jet | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 196 – Anna Wintour, Mark Teixeira | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 195 – Christina Applegate, Brendan Benson, Patton Oswalt | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 194 – Renee Zellweger, Gary Mule Deer | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 192 – Mike Myers, Ken Burns | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 191 – Donald Trump, Diane Kruger, Billy Currington, a Top Ten List presented by Britney Spears | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 190 – Quentin Tarantino, Eric Ripert, Robert Cray | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 189 – Regis Philbin, Ted Alexandro, Dave Matthews Band | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 188 – Adam Sandler, Cage the Elephant | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 187 – Amy Adams, Tom Dreesen, Elbow | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 186 – Katie Couric, Silversun Pickups | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 185 – Eric Bana, Dave Matthews Band, a Top Ten List presented by Chicago White Sox star Mark Buehrle | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 184 – Amy Poehler, Nick Griffin, Judy Collins | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 183 – Sean “Diddy” Combs, Vera Farmiga, Ginuwine with Missy Elliott | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 182 – Tracy Morgan, Leslie Mann, Diane Birch | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 181 – Kevin Spacey, Jesse James, the Flatlanders, a Top Ten List presented by Stewart Cink | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 180 – Katherine Heigl, Jeff Altman, Spinnerette | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 179 – Tom Arnold, Metric, a Top Ten List presented by Dave’s mom Dorothy | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 178 – Anderson Cooper, Anna Paquin, Grizzly Bear | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 177 – Paul McCartney, a Top Ten List presented by Bruce Willis | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 176 – Edie Falco, Michael Showalter, Wilco with Feist | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 175 – Jonah Hill, Gar Ryness, Kelly Clarkson | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 174 – Rainn Wilson, Larry Miller, Maxwell | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 173 – Daniel Radcliffe, Veronika Part, Levon Helm, a Top Ten List presented by Bruno | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 172 – Queen Latifah, Emma Watson | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 171 – Sacha Baron Cohen, Joel McHale | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 170 – Serena Williams, Hayden Panettiere, Conor Oberst and the Mystic Valley Band | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 169 – Martin Short, Regina Spektor | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 168 – Johnny Depp, Megan Fox | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 167 – Ray Romano, St. Vincent | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 166 – Sandra Day O’Connor, MSTRKRFT with John Legend, a Top Ten List presented by Lucas Glover | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 165 – Samuel L. Jackson, Emeril Lagasse, Iggy Pop & the Brighton Port Authority | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 164 – Jada Pinkett Smith, Michael Cera, the Sounds | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 163 – Danny DeVito, Bear Grylls, Phoenix | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 162 – Ryan Reynolds, Padma Lakshmi, the Eels | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 161 – Michelle Pfeiffer, Judah Friedlander, Ian McLagan & the Bump Band | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 160 – Jack Black, M.A. Sanjayan | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 159 – Sandra Bullock, Pete Correale, P.J. Harvey & John Parish | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 158 – Denzel Washington, the Jonas Brothers, a Top Ten List with Regis Philbin | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 157 – Kathy Griffin, Stupid Human Tricks, Sonic Youth, an NBA Finals report by Phoenix Suns’ Steve Nash | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 156 – Julia Roberts, Black Eyed Peas | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 155 – Howard Stern, Mos Def | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 154 – Paris Hilton, Calvin Borel, Steven Wright | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 153 – Elvis Costello, a Top Ten List presented by Neil Patrick Harris | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 152 – Jessica Biel, Zach Galifianakis, Steve Earle | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 151 – Jack Hanna, John Krasinski | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 150 – Bill Cosby, Helio Castroneves, Melody Gardot | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 149 – Ricky Gervais, Green Day | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 148 – Amy Sedaris, Ed Helms, Jean Redpath | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 147 – Stephen Colbert, General Motors Vice Chairman Bob Lutz, Grizzly Bear | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 146 – Jane Fonda, Piedmont Bird Callers, Kenny Chesney | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 145 – Ben Stiller, White Rabbits | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 144 – John Goodman, Tommy Tiernan, Mastodon | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 143 – Kid Scientists, Teri Hatcher, Rick Ross with Magazeen, a Top Ten List presented by Ron Howard | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 142 – Robin Williams, Wynton Marsalis | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 141 – Alec Baldwin, Maya Rudolph, Chrisette Michele | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 140 – Tom Hanks, the Killers | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 139 – Matthew Broderick, Brian Regan, Chris Cornell | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 138 – Norm MacDonald, a Top Ten List presented by Leonard Nimoy, Animal Collective | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 137 – Bruce Willis, Ben Harper & Relentless7 | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 136 – Liev Schreiber, Dr. Sanjay Gupta, Franz Ferdinand | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 135 – Gordon Ramsay, Chris Pine, Keri Hilson with Kanye West | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 134 – Kiefer Sutherland, Jim Norton, Bat for Lashes | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 133 – Regis Philbin, a performance by the Broadway cast of “Hair” | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 132 – Jennifer Garner, Tesla Motors CEO Elon Musk, Manchester Orchestra | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 131 – Dolly Parton, Zachary Quinto | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 130 – Matthew Fox, Carol Leifer, the All-American Rejects, a Top Ten List presented by Matthew Stafford | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 129 – Michael Keaton, Lily Allen | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 128 – Jamie Foxx, Lauren Conrad, the Dead | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 127 – Beyonce, Jim Parsons | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 126 – Nathan Lane, Tinted Windows | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 125 – Jeff Goldblum, Jeff Dunham | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 124 – Russell Crowe, Joe Wong | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 123 – Matthew Perry, Elisha Cuthbert, Rascal Flatts | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 122 – Drew Barrymore, Jack McBrayer, Neko Case | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 121 – Kelly Ripa, Bill Scheft, Yeah Yeah Yeahs | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 120 – Zac Efron, Mike Golic and Mike Greenberg, A.C. Newman with Nicole Atkins | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 119 – Denis Leary, Diana Krall | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 118 – Michael J. Fox, the Fray | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 117 – Marg Helgenberger, Francisco Palacios, Ray LaMontagne | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 116 – Bill O’Reilly, Marianne Faithfull | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 115 – Seth Rogen, Tom Dreesen, Adele | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 114 – Christina Applegate, Jim Gaffigan, Jesse Harris with Norah Jones | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 113 – Mary Tyler Moore, Blake Lively, White Lies | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 112 – Hugh Laurie, Bloc Party | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 111 – David Spade, Richard Zoglin, David Sanborn and Sam Moore | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 110 – Billy Crystal, Kara DioGuardi, a Top Ten List presented by Owen Wilson | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 109 – Craig Ferguson, Ginnifer Goodwin, Modest Mouse | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 108 – Julia Roberts, Bell X1 | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 107 – Nicolas Cage, Rachel Maddow | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 106 – Will Ferrell, Cursive | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 105 – Andy Samberg, Paul Teutul Sr., the Broadway cast of “West Side Story” | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 104 – Tom Brokaw, An Horse | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 103 – Stupid Pet Tricks, Paul Rudd, Razorlight | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 102 – Russell Brand, Jack Hanna | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 101 – Jason Segel, Brian Kiley, U2 | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 100 – Jon Stewart, U2, a Top Ten List featuring 10 Team USA members from the World Baseball Classic | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 99 – Dr. Phil McGraw, U2 | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 98 – Felicity Huffman, Artie Lange, U2 | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 97 – Katie Couric, U2 | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 96 – Barbara Walters, Mike Birbiglia, Shemekia Copeland | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 95 – David Spade, Jeffrey Sachs, David Sanborn with Sam Moore | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 94 – Donald Trump, Antony and the Johnsons | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 93 – Bonnie Hunt, M. Ward | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 92 – Ellen Pompeo, Daytona 500 winner Matt Kenseth, Willie Nelson with Asleep at the Wheel | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 91 – Martha Stewart, Jake Johannsen, Matt Nathanson | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 90 – Chris Russo, the Jonas Brothers, Ashford & Simpson | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 89 – Joaquin Phoenix, Bar Refaeli, Anthony Hamilton | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 88 – The crew of US Airways “Miracle On The Hudson” Flight 1549, Heartless Bastards | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 87 – Naomi Watts, Danny McBride, 2009 Sports Illustrated Swimsuit Issue cover reveal | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 86 – Dakota Fanning, Keith Alberstadt, Beirut | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 85 – Isla Fisher, extreme fisherman Matt Watson, Mark Olson and Gary Louris, a Top Ten List presented by Lil’ Wayne | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 84 – Joe Torre, Demetri Martin, Lyle Lovett and John Hiatt | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 83 – Rod Blagojevich, Richard Jenkins | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 82 – Ben Roethlisberger, Steve Martin | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 81 – Mary Hicks, the Gaslight Anthem | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 80 – Renee Zellweger, Tony Dungy, Graham Nash sits in with the band | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 79 – Lauren Graham, Guy Fieri, MENEW | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 78 – Evangeline Lilly, Seth Meyers, Andrew Bird | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 77 – Brian Williams, Ben Kweller | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 76 – Zach Braff, Arj Barker, The Airborne Toxic Event | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 75 – Kyra Sedgwick, Gwen Ifill | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 74 – Clint Eastwood, Randy Rogers Band | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 73 – Salma Hayek, Jimmie Walker | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 72 – Billy Crystal, Kara DioGuardi | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 71 – Kiefer Sutherland, Wendy Liebman | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 70 – Kate Winslet, Marv Albert | | 0 | 13 years |
| Late Show with David Letterman Season 16 Episode 69 – Ricky Gervais, Rose Byrne, Okkervil River | | 0 | 13 years |
